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凋亡在B淋巴细胞的发育及肿瘤发生中的作用非常重要。B淋巴细胞肿瘤的发生和化疗耐药机制通常包括Bcl-2蛋白家族失调和p53/p14ARF通路改变。然而Burkitt淋巴瘤细胞株Raji细胞凋亡通路中Apaf-1或DFF-40异常,而非Bcl-2、p53异常诱发凋亡耐受的研究结果令人关注。进一步探索B细胞淋巴瘤凋亡失调的机制,开发新的靶向治疗药物,或将为B细胞淋巴瘤的治疗带来新的希望。
Apoptosis plays a very important role in the development of B lymphocytes and tumorigenesis. The pathogenesis of B lymphocytic tumors and chemoresistance mechanisms usually include the imbalance of Bcl-2 protein family and the change of p53 / p14ARF pathway. However, the results of the study on the abnormal apoptosis-inducing ability of Apaf-1 or DFF-40 in Burkitt’s lymphoma cell line Raji but not Bcl-2 are of concern. To further explore the mechanism of apoptosis in B-cell lymphoma, to develop new targeted therapies, or for the treatment of B-cell lymphoma brings new hope.