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目的 探讨经导管肝动脉栓塞化疗术 (TACE)对肝细胞癌 (HCC)细胞凋亡相关蛋白fas ,bax和bcl -xl表达的影响 ,评价TACE对肝细胞癌的疗效。方法 经病理证实的肝细胞癌 63例 ,包括单纯手术组 42例 ,TACE组 2 1例 (为TACE治疗后 2次有手术机会而行切除者 ) ;采用免疫组织化学SP法检测标本fas ,bax和bcl -xl的表达情况 ,将 2组结果进行对照分析。结果 TACE组fas表达阳性率为 47.62 % ( 10 / 2 1) ,单纯手术组fas表达阳性率为 2 1.43 % ( 9/ 42 ) ,二者之间有显著性差异 (Ρ <0 .0 5 ) ,TACE组明显高于单纯手术组 ;TACE组bcl -xl表达阳性率为 2 3 .81% ( 5 / 2 1) ,单纯手术组阳性率为 5 4.76% ( 2 3 / 42 ) ,二者之间亦有显著性差异 (Ρ <0 .0 5 ) ,TACE组明显低于单纯手术组 ;bax的表达阳性率在单纯手术组和TACE组无显著性差异 (Ρ >0 .0 5 )。结论 TACE治疗可以促进肝癌细胞fas表达增高 ,使bcl -xl表达降低 ,从而在总体上增加肝癌细胞凋亡率 ,促使肿瘤缩小。关于TACE治疗对bax的影响有待进一步研究
Objective To investigate the effect of transcatheter arterial chemoembolization (TACE) on the expression of fas, bax and bcl-xl in hepatocellular carcinoma (HCC) and to evaluate the therapeutic effect of TACE on hepatocellular carcinoma. Methods Totally 63 hepatocellular carcinomas confirmed by pathology, including 42 cases of simple operation group and 21 cases of TACE group (twice for surgical treatment after TACE treatment), were detected by immunohistochemical SP method for fas, bax And bcl -xl expression, the two groups of results for the control analysis. Results The positive expression rate of fas in TACE group was 47.62% (10/21). The positive expression rate of fas in fascial operation group was 2.14% (9/42), the difference was significant (P <0.05) . The positive rate of bcl-xl in TACE group was 23.81% (5/21), the positive rate in pure surgery group was 5. 4.76% (23/42) There was also a significant difference between the two groups (P <0.05). The TACE group was significantly lower than that of the surgery alone group. The positive rate of bax expression was not significantly different between the surgery group and the TACE group (Ρ0.05). Conclusion TACE treatment can promote fas expression of hepatocellular carcinoma cells and decrease the expression of bcl-xl, which can increase the apoptosis rate of hepatocellular carcinoma cells in general and reduce the tumor size. The impact of TACE treatment on bax needs further study