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过多的钙离子进入细胞可出现许多病理现象,如细胞缺血性坏死、高血压和心绞痛。临床应用的钙阻滞剂(CB)具有选择性作用,既非完全阻断钙进入细胞,也非对所有的组织和器官都同样有作用。自1964年首次描述 CB 后,具有更精确、更有选择性作用的新 CB 正在继续发展和进行实验中,其治疗指征也正在迅速扩大。本文综述外科领域中 CB 的临床药理作用和应用近况。定义和作用机理钙阻滞剂(CB)是一大组能阻止细胞外钙进入细
Too many calcium ions enter the cell can appear many pathological phenomena, such as cell ischemic necrosis, hypertension and angina pectoris. The clinical use of calcium blockers (CB) has a selective effect that neither blocks calcium completely into the cell nor does it have the same effect on all tissues and organs. Since CB was first described in 1964, new CBs with more precise and selective effects continue to evolve and undergo experiments, and their indications of treatment are rapidly expanding. This article reviews the clinical pharmacology of CB in the surgical field and its current status. Definition and Mechanism of Action Calcium blockers (CBs) are a large group that prevents extracellular calcium from entering the cell