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目的探讨急性冠脉综合征患者血妊娠相关血浆蛋白-A(PAPP-A)和可溶性CD40配体(sCD40L)与冠脉狭窄程度的相关性。方法 106例冠心病患者分为两组,稳定性心绞痛31例作为对照组,急性冠脉综合征75例作为观察组。进行冠脉狭窄评分,测定血PAPP-A和sCD40L的浓度。结果观察组患者的PAPP-A和sCD40L均比对照组明显升高(P<0.01)。观察组Gensini评分平均为(104.6±39.7)分,与PAPP-A呈正相关(r=0.2719,P<0.05);与sCD40L呈正相关(r=0.7328,P<0.05)。结论急性冠脉综合征患者血PAPP-A和sCD40L的表达与冠脉狭窄程度密切相关。
Objective To investigate the correlation between serum levels of plasma protein-A (PAPP-A) and soluble CD40 ligand (sCD40L) and coronary artery stenosis in patients with acute coronary syndrome. Methods 106 cases of coronary heart disease patients were divided into two groups, 31 cases of stable angina pectoris as control group and 75 cases of acute coronary syndrome as observation group. Coronary stenosis scores were determined and the concentrations of blood PAPP-A and sCD40L were determined. Results The PAPP-A and sCD40L in the observation group were significantly higher than those in the control group (P <0.01). The mean Gensini score in the observation group was (104.6 ± 39.7) points, positively correlated with PAPP-A (r = 0.2719, P <0.05), and positively correlated with sCD40L (r = 0.7328, P <0.05). Conclusion The expression of PAPP-A and sCD40L in patients with acute coronary syndrome is closely related to the degree of coronary artery stenosis.