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目的观察手术联合放射性125I粒子植入治疗脑恶性肿瘤对患者术后精神症状的影响。方法将脑恶性肿瘤患者200例随机分为试验组和对照组各100例。2组患者均给予常规对症治疗,待患者条件适宜时给予大脑开颅恶性肿瘤切除术,试验组术后额外行放射性125I粒子植入术。2组术后给予支持治疗和分级护理,对比2组临床疗效和精神症状。结果试验组治疗后生存期长于对照组,总有效率高于对照组,复发率低于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。试验组焦虑症状和抑郁症状发生率均低于对照组,差异均有统计学意义(P<0.05)。结论手术联合放射性125I粒子植入方式治疗脑恶性肿瘤具有良好的治疗效果,并可有效降低术后精神症状发生率。
Objective To observe the effect of surgery and radioactive 125I seed implantation on postoperative psychiatric symptoms in patients with malignant brain tumors. Methods 200 patients with malignant brain tumors were randomly divided into experimental group and control group of 100 cases. The patients in both groups were given conventional symptomatic treatment. Excision of craniotomy was given to the patients under suitable conditions. Radioactive 125I seed implantation was performed in the experimental group after operation. Two groups were given postoperative supportive care and grading nursing. The clinical efficacy and psychiatric symptoms were compared between the two groups. Results The survival time of the experimental group was longer than that of the control group, the total effective rate was higher than that of the control group, the recurrence rate was lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The incidence of anxiety symptoms and depressive symptoms in the experimental group were lower than those in the control group, the differences were statistically significant (P <0.05). Conclusion The combined operation of radioactive 125I seed implantation for the treatment of malignant brain tumors has a good therapeutic effect and can effectively reduce the incidence of postoperative psychiatric symptoms.