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应用免疫组织化学方法观察64例贲门癌组织中的胃泌素型癌细胞,并测定了血清胃泌素浓度.结果显示:21.88%(14/64)的贲门癌组织中存在胃泌素型癌细胞;贲门癌患者术前血清胃泌素浓度较正常人为高(P<0.01).术后继续升高,4周达顶峰,8周恢复正常水平.作者对癌组织中胃泌素型癌细胞与血清胃泌素水平之间关系进行了探讨,胃泌素型癌细胞阳性者贲门癌血清胃泌素水平为196.08±69.50ng/L,胃泌素型癌细胞阴性者为168.92±59.74ng/L(P>0.05).结果提示;胃泌素型癌细胞不影响贲门癌的血清胃泌素浓度.
Immunohistochemical method was used to observe gastrin-type cancer cells in 64 cases of gastric cardia cancer and determine the concentration of serum gastrin. The results showed that gastrin-type cancer was present in 21.88% (14/64) of cardiac cancer tissues. Preoperative serum gastrin concentrations in patients with cardiac cancer were higher than those in normal subjects (P<0.01). Postoperative rise continued, peaked at 4 weeks, and returned to normal at 8 weeks. The authors compared gastrin-type cancer cells in cancer tissues. The relationship between serum gastrin and serum gastrin levels was investigated. Serum gastrin levels were 196.08±69.50ng/L for gastrin cancer-positive patients and 168.92±59.74ng/L for patients with gastrin-type cancer cells. L (P>0.05). The results suggest that gastrin-type cancer cells do not affect serum gastrin concentrations in cardiac cancer.