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目的探讨急性心肌梗塞（ＡＭＩ）患者静脉溶栓治疗前后ＱＴ间期离散度（ＱＴｄ）变化及对预后的影响。方法１５３例ＡＭＩ患者分为溶栓再通组，未通组及非溶栓组，测定其溶栓前后的ＱＴｄ，并与非溶栓组ＱＴｄ比较。结果溶栓治疗再通后ＱＴｄ明显减小，而未通组及非溶栓组ＱＴｄ增大，且后两组间ＱＴｄ比较差异无显著性（Ｐ＞０．０５）。ＱＴｄ增大者发生室性快速心律失常比率增大。结论ＡＭＩ患者ＱＴｄ明显增大，但静脉溶栓再通后，随心肌缺血改善，ＱＴｄ明显减小，同时室性快速心律失常发生率降低。
Objective To investigate the changes of QTd before and after intravenous thrombolysis in patients with acute myocardial infarction (AMI) and its effect on prognosis. Methods A total of 153 AMI patients were divided into thrombolytic group, failed group and non-thrombolytic group. QTd before and after thrombolytic therapy was measured and compared with QTd in non thrombolysis group. Results QTd decreased significantly after thrombolytic therapy recanalization, while QTd increased in non-thrombolytic group and non-thrombolytic group. There was no significant difference in QTd between the two groups (P> 0.05). The rate of ventricular tachyarrhythmia increases with an increase in QTd. Conclusions The QTd of patients with AMI is obviously increased. However, after thrombolysis recanalization, the QTd obviously decreases with the improvement of myocardial ischemia, and the incidence of ventricular tachyarrhythmias decreases.