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Background Studies have shown that the apo(a) gene(LPA) rs3798220 polymorphism is associated with thelevels of lipids and the curative effect of statin therapy for carotid atherosclerosis(CAS). Whether carriers ofan apo(a) variant benefit more from statin remains unclear. Methods One hundred and three patients with CAS were recruited from April 2012 to April 2013 in the Shunde First Peoples Hospital Affiliated to Southern Medical University in Foshan. All patients were administered atorvastatin 20 mg/d and were followed-up for 2years. with the levels of plasma Lp(a), total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL),low density lipoprotein(LDL). LPA rs3798220 genotypes of all patients were analyzed. Results Statin treatment significantly reduced the levels of IMT, TC, TG, LDL and increased the level of HDL, but statin treatment did not reduce the level of Lp(a). According to the curative effect of statin therapy in patients with CAS,rs3798220 polymorphism had a certain influence on LDL and TC levels, but not on the improvement of the IMT,TG, HDL and Lp(a). Conclusion Rs 3798220 polymorphism has a certain impact on the curative effects of statin, on LDL and TC levels.
Whether carrier ofan apo (a) variant benefit more from statin remains unclear . Methods One hundred and three patients with CAS were recruited from April 2012 to April 2013 in the Shunde First Peoples Hospital Affiliated to Southern Medical University in Foshan. All patients were administered atorvastatin 20 mg / d and were followed-up for 2 years. With the levels of plasma Lp (a), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL). LPA rs3798220 genotypes were all reduced in the patients IMT, TC, TG, LDL and increased the level of HDL, but statin treatment did not reduce the level of Lp (a). According to the curative effect of statin therapy in patients with CAS, rs3798220 polymorphism had a cer tain influence on LDL and TC levels, but not on the improvement of the IMT, TG, HDL and Lp (a). Conclusion Rs 3798220 polymorphism has a certain impact on the curative effects of statin, on LDL and TC levels.