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对33例足月窒息新生儿进行长程EEG监测和定量分析,结果表明伴有中~重度HIE及惊厥发作组背景EEG异常率显著增加,重度异常者预后不良。重度窒息及伴有中~重度HIE或惊厥发作组阵发性异常放电出现率显著增加。定量分析表明无或轻度HIE患儿有轻度的睡眠周期紊乱,背景活动恶化时则可出现明显睡眠周期异常。表明新生儿窒息时的缺氧缺血性改变可导致一过性或持续性脑功能障碍,长程EEG监测和定量分析有助于指导临床诊断治疗及判断预后。
Long-term EEG monitoring and quantitative analysis of 33 full-term asphyxia neonates showed that there was a significant increase in the background abnormal EEG with moderate-severe HIE and convulsion-seizure group, and poor prognosis. Severe asphyxia and accompanied by moderate or severe HIE or seizures group increased the incidence of paroxysmal anomalies. Quantitative analysis showed mild or no sleep disturbances in children with or without mild HIE and significant sleep-cycle abnormalities when background activity worsens. The results suggest that hypoxic-ischemic changes during neonatal asphyxia can lead to transient or persistent brain dysfunction. Long-term EEG monitoring and quantitative analysis can help to guide the clinical diagnosis and prognosis.