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[目的]探讨垂体瘤转化基因(PTTG)和p53蛋白在大肠癌中的表达及其淋巴结转移的关系。[方法]采用免疫组织化学法检测71例大肠癌标本和42例癌旁正常黏膜组织的PTTG和p53蛋白的表达水平,并分析其与临床病理学特征的关系。[结果]PTTG蛋白和p53在大肠癌组织中的过度表达率分别为73.2%和70.4%,均明显高于其在正常大肠黏膜组织中的表达(7.1%和0),差异具有显著性(P<0.01)。PTTG的过度表达与淋巴结转移明显相关(P<0.001),p53的过度表达则与淋巴结转移不相关(P>0.05)。[结论]PTTG在大肠癌组织中呈过度表达,并与淋巴结转移有关,可以作为判断大肠癌是否有淋巴结转移的分子指标。
[Objective] To investigate the relationship between the expression of PTTG and p53 protein in colorectal carcinoma and their lymph node metastasis. [Methods] The expressions of PTTG and p53 protein in 71 specimens of colorectal cancer and 42 specimens of adjacent normal mucosa were detected by immunohistochemistry. The relationship between them and the clinicopathological features was analyzed. [Results] The overexpression rates of PTTG protein and p53 in colorectal carcinoma were 73.2% and 70.4%, respectively, which were significantly higher than those in normal colorectal mucosa (7.1% and 0), respectively <0.01). Overexpression of PTTG was significantly associated with lymph node metastasis (P <0.001), and overexpression of p53 was not associated with lymph node metastasis (P> 0.05). [Conclusion] PTTG is overexpressed in colorectal cancer tissues and related to lymph node metastasis, which can be used as a molecular index to determine whether there is lymph node metastasis in colorectal cancer.