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克罗米芬(CC)应用于体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)的促排卵方案中,比常规方案更简单、方便、经济,可重复性高。但CC对子宫内膜的负面影响,使其在IVF中的应用受到限制,而针对这些负面影响采取的改善措施是否有效,也存在争议。CC应用于微刺激方案中与常规促排卵方案比较,减少了Gn用量,缩短了Gn天数,减少了卵巢过度刺激综合征(OHSS)的发生,在微刺激方案中,促排卵后期加用CC能够更好地改善抗雌激素作用及抑制LH峰,降低周期取消率,获得较多的卵子及较好的子宫内膜厚度。
Clomiphene citrate (CC) is more simple, convenient, economical and reproducible in ovulation induction than IVF-ET in vitro. However, the negative effect of CC on endometrium limits its application in IVF, and it is controversial whether the improvement measures applied to these negative effects are effective. Compared with the conventional ovulation induction program, the application of CC in the micro-stimulation regimen reduced Gn dosage, shortened Gn days and decreased the occurrence of ovarian hyperstimulation syndrome (OHSS). In the micro-stimulation program, Better anti-estrogen effect and inhibit LH peak, reduce the cycle cancellation rate, get more eggs and better endometrial thickness.