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1975年我们合成了DDT的类似物——三氯杀虫酯(代号7504)。室内药效试验结果,对家蝇(Musca domestica vicina macq)的LD_(50)为4.89—5.89微克/头(DDT为50微克/头);用残膜法处理家蝇KT_(30)为23分44秒(DDT为60分)。处理后的残膜室内放置60天,处理家蝇KT_(30)为48分26秒(DDT为95分5秒)。1977年7—8月份进行了扩大药效试验。在住户和畜舍内以2克/米~2药量作滞留喷洒,对蚊、蝇成虫的药效可维持一个月左右。 “7504”在生物体内容易降解。家蝇试验SR值为15.8(DDT为2.2)。以DDT作对比,用含相同药量100ppm的鸡饲料,任其自由取食15天后,分析DDT在鸡体内的累积量为495.5ppm;而“7504”在鸡体内则没有发现。以1000ppm的“7504”喂15天后,在胸肌及肝内仅有微量存在,脂肪内未发现,而粪便内则达167ppm。如用胶囊每天强迫饲喂2克,7天后肝脏内含0.5ppm。脂肪内未发现。粪便内达625ppm。“7504”与鸡肝匀浆,在37℃条件下培育10分钟,可降解85％以上,培育20分钟有97％被降解。
In 1975 we synthesized DDT analog - trichloro-insecticide (codenamed 7504). The indoor efficacy test showed that the LD 50 of Musca domestica vicina macq was 4.89-5.89 μg / head (DDT was 50 μg / head), while that of housefly KT 30 was 23 points 44 seconds (DDT is 60 minutes). The treated residual membrane chamber was left for 60 days and the housefly KT 30 was treated for 48 minutes 26 seconds (DDT 95 minutes 5 seconds). From July to August 1977, an extended efficacy trial was conducted. In households and livestock barn to 2 g / m ~ 2 dose for stranded spray, mosquito, adult fly efficacy can be maintained for about a month. “7504” is easily degraded in living organisms. The housefly test SR value of 15.8 (DDT of 2.2). DDT as a control, with the same dose of 100ppm chicken feed, let it free to eat 15 days after the analysis DDT in chicken body cumulation was 495.5ppm; and “7504” in the chicken body was not found. After being fed for 15 days at 1000 ppm “7504”, only trace amounts were present in the pectoral muscles and the liver, not found in the fat, while in the stool it reached 167 ppm. Such as capsules with forced daily feeding 2 grams, 7 days after the liver contains 0.5ppm. No fat found. Fecal up to 625ppm. “7504” was homogenized with chicken liver and incubated at 37 ° C for 10 minutes, degradable more than 85% and 97% for 20 minutes.