The results and main findings of studies reported in the literature in relation to the deposition of calcium phosphate onTi in simulated body fluids are summarized. The effects of the surface hydroxyl groups and the sign of surface chargeon the nucleation of calcium phosphate are reviewed. One major controversy among the conclusions of differentstudies is the order of adsorption of the calcium ions and the phosphate ions in the initial stage of immersion. Asimple model based on the amphoteric nature of the hydroxyl groups on Ti is proposed in an attempt to delineatethe nucleation process for calcium phosphate on Ti in simulated body fluids. HPO42- ions interact with the hydroxylgroups via ion exchange and/or electrostatic attraction, and Ca2+ ions, via electrostatic attraction only. There is nopreferential order of adsorption. Seemingly inconsistent results in different studies possibly arise from different priortreatments of the samples, which affect the adsorption properties. The results and main findings of studies reported in the literature in relation to the deposition of calcium phosphate onTi in simulated body fluids are summarized. The effects of the surface hydroxyl groups and the sign of surface chargeon the nucleation of calcium phosphate are reviewed. One major controversy among the conclusions of different studies is the order of adsorption of calcium ions and the phosphate ions in the initial stage of immersion. Asimple model based on the amphoteric nature of the hydroxyl groups on Ti is proposed in an attempt to delineate the nucleation process for calcium phosphate on Ti in simulated body fluids. HPO42-ions interact with the hydroxylgroups via ion exchange and / or electrostatic attraction, and Ca2 + ions, via electrostatic attraction only. There is nopreferential order of adsorption. Seemingly inconsistent results in different studies may arise from different priortreatments of the samples, which affect the adsorption properties.