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目的探讨小剂量激素联合环磷酰胺治疗系统性红斑狼疮(SLE)近期临床疗效。方法 40例SLE患者给予口服醋酸泼尼松片,每天0.2mg/kg;注射用环磷酰胺0.5g,加入250ml葡萄糖注射液静脉滴注,每2周给药1次。疗程3个月,观察患者临床症状改善及不良反应。结果患者治疗前SLEDAI积分为(14.90±2.23)分,疗程结束时为(5.93±1.52)分,差异存在统计学意义(P<0.05)。40例患者显效5例、有效30例和无效5例,总有效率为87.50%。治疗期间出现白细胞减少1例、柯兴氏症1例、感染1例、失眠2例、月经失调2例和胃肠道反应3例。结论小剂量激素联合环磷酰胺治疗系统性红斑狼疮疗效满意,不良反应少,值得临床推广应用。
Objective To investigate the short-term clinical efficacy of low-dose hormone combined with cyclophosphamide in the treatment of systemic lupus erythematosus (SLE). Methods 40 SLE patients were given oral prednisone acetate tablets daily 0.2mg / kg; injection of cyclophosphamide 0.5g, add 250ml glucose injection intravenously, administered once every two weeks. Treatment for 3 months to observe the clinical symptoms and adverse reactions. Results The score of SLEDAI was (14.90 ± 2.23) before treatment and (5.93 ± 1.52) at the end of treatment, the difference was statistically significant (P <0.05). Forty patients were markedly effective in 5 cases, effective in 30 cases and ineffective in 5 cases, the total effective rate was 87.50%. 1 cases of leukopenia, 1 case of Cushing’s disease, 1 case of infection, 2 cases of insomnia, 2 cases of menstrual disorders and 3 cases of gastrointestinal reaction during treatment. Conclusion Small dose of hormone combined with cyclophosphamide in the treatment of systemic lupus erythematosus with satisfactory results, fewer adverse reactions, it is worthy of clinical application.