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目的:研究石油作业环境对女性习惯性流产的遗传毒性。方法:随机选择习惯性流产的石油作业女性38人和正常的育龄女性20人,检测其外周血淋巴细胞姐妹染色单体互换,记数SCE发生率。结果:观察组的外周血淋巴细胞SCE发生率为8.81±0.35,明显高于对照组(P<0.05)。结论:SCE的发生可作为石油作业习惯性流产女性染色体结构稳定性的检测指标。石油作业环境对女性生育具有遗传毒性。
OBJECTIVE: To study the genotoxicity of habitual abortion of women in petroleum operating environment. Methods: 38 oil-treated women and 20 normal women of childbearing age who were randomly selected for habitual abortion were tested for their sister chromatid exchange of peripheral blood lymphocytes and the incidence of SCE. Results: The incidence of SCE in peripheral blood lymphocytes in observation group was 8.81 ± 0.35, which was significantly higher than that in control group (P <0.05). Conclusion: The occurrence of SCE can be used as a measure of the structural stability of female chromosomes in habitual abortion in petroleum operations. The oil working environment is genotoxic to female fertility.