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目的观察双氢青蒿素哌喹片对云南省恶性疟的疗效和安全性。方法在云南边境抗药性恶性疟流行区选择恶性疟患者69例,用双氢青蒿素哌喹片2d 4次疗法治疗并追踪观察28d。结果治愈率为100%,平均退热时间(34.99±16.51)h;平均无性体原虫转阴时间(33.14±11.91)h;配子体转阴率为95.46%,临床及实验室检查均未见明显不良反应。结论双氢青蒿素哌喹片2d 4次疗法治疗云南恶性疟具有高效、速效、低毒、疗程短、服药依从性高、配子体转阴率高等优点。
Objective To observe the efficacy and safety of dihydroartemisinin and piperaquine tablet in the treatment of falciparum malaria in Yunnan Province. Methods Sixty - nine patients with falciparum malaria were selected in the endemic area of drug - resistant falciparum malaria in Yunnan border. The patients were treated with dihydroartemisinin and piperaquine for 2 days and followed up for 28 days. Results The cure rate was 100%, the mean time to fever was (34.99 ± 16.51) h, the mean time for anaplasmosis was 33.14 ± 11.91 h, and the rate of gametophyte negative conversion was 95.46%. There was no obvious clinical and laboratory abnormalities reaction. Conclusions Dihydroartemisinine and piperaquine tablets for 2 days and 4 times for the treatment of P. falciparum in Yunnan Province have the advantages of high efficiency, quick response, low toxicity, short course of treatment, high medication compliance and high gametomas conversion rate.