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目的了解徐州地区慢性乙型肝炎（ＣＨＢ）患者中乙型肝炎病毒（ＨＢＶ）、丙型肝炎病毒（ＨＣＶ）重叠感染情况。方法对徐州地区２４７例慢性乙型肝炎患者（ＣＨＢ）进行血清丙型肝炎抗体（抗－ＨＣＶ）及丙型肝炎病毒（ＨＢＶ、ＨＣＶ）重叠感染与单纯ＨＢＶ感染患者的临床资料进行比较。结果①徐州地区ＨＢＶ、ＨＣＶ重叠感染率为１２．９６％（３２／２４７）。②重叠感染者的年龄、血清丙氨酸氨基转移酶（ＡＬＴ）、血清胆红素（ＳＢ）及黄疸发生率与单纯ＨＢＶ感染者之间无明显差异（Ｐ＞０．０５）。③重叠感染对ＨＢＶ复制无抑制现象，而重叠感染者血清抗－ＨＢｓ检出率３４．３８％（１１／３２）明显高于单纯ＨＢＶ感染者６．５１％（１４／２１５）（Ｐ＜０．０５）。结论重叠感染在徐州地区并不少见，ＨＣＶ重叠ＨＢＶ感染后未加重患者的病情，ＨＣＶ对ＨＢＶ复制无抑制作用，但可促进部分患者ＨＢｓＡｇ向抗－ＨＢｓ的转化。
Objective To understand the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) in Chronic Hepatitis B (CHB) patients in Xuzhou area. Methods The clinical data of 247 patients with chronic hepatitis B (CHB) from Xuzhou area were compared with those of patients with HBV infection by overlapping infection of hepatitis C virus (HCV), hepatitis C virus (HCV) and hepatitis C virus (HCV). Results ① The overlap rate of HBV and HCV in Xuzhou was 12.96% (32/247). ② There was no significant difference in the age, ALT, SB and jaundice between patients with HBV infection and those with HBV infection (P> 0.05). (3) Over-infection did not inhibit the replication of HBV, but the positive rate of anti-HBs in overlap infection was 34.38% (11/32), significantly higher than that in HBV infected patients (6.51%, 14/215) .05). Conclusions It is not uncommon for over-infection in Xuzhou. HCV infection did not aggravate HBV infection. HCV had no inhibitory effect on HBV replication but could promote the transformation of HBsAg to anti-HBs in some patients.