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目的：探讨小剂量左旋甲状腺素治疗新生儿期暂时性甲状腺功能减退症的临床疗效。方法选择我科2008年6月-2012年6月经新生儿筛查确诊为新生儿期暂时性甲状腺功能减退症42例作为实验组，对照组为甲状腺功能发育正常的新生儿42例，实验组采用小剂量左旋甲状腺素（每日8～9 u g/k g）治疗，对照组未给予任何治疗。结果实验组2～3岁后停药1个月，B超、E C T示甲状腺发育正常，骨龄正常，发育商（D Q）平均为105.3±15.3，与对照组比较差异无统计学意义（P＞0.05）。停药后1年随访，血T3、T4、T S H正常。结论小剂量左旋甲状腺素治疗新生儿期暂时性甲状腺功能减退症的临床疗效疗效显著，值得临床推广。“,”Objective: To investigate the clinical efficacy of smal doses of levothyroxine in treatment of neonatal transient hypothyroidism. method: Select 42 cases neonatal transient hypothyroidism diagnosed with newborn screening in our department from June 2008 to june 2012 as the experimental group and 42 cases of normal thyroid functionneonatal as the Control group. Experimental group was accpected a smal dose of levothyroxine (daily 8~9ug/kg). The control group received no treatment Result: Experimental group withdrawal a month after 2 to 3 years, Ultrasound, ECT showing normal development of the thyroid, bone age is normal, developmental quotient (DQ) averaged 105.3 ± 15.3, compared with the control group, the difference was not statistical y significant (P> 0.05). 1-year fol ow-up after treatment, serum T3, T4, TSH is normal. Conclusion: The clinical efficacy of smal doses of levothyroxine in treatment of neonatal transient hypothyroidism was notable,and worthy of clinical spread.