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目的探讨循期阴阳序贯疗法对卵巢早衰患者性功能的影响。方法采用随机、对照原则,选60例患者分为中药组、中西医结合组、西药组,中药组选择左归丸及右归丸为治疗用药,西药组给予雌孕激素序贯疗法,中西医结合组中西药同用。所有患者均以3个周期为1个疗程,进行总疗效观察判定;采用酶联免疫吸附法检测治疗前后FSH和E2以及性功能积分量化比较。结果卵巢早衰患者中药组有效率为60%,中西医结合组有效率为75%,西药组有效率为45%;中药组与中西医结合组比较差别无显著意义(P>0.05),中药组、中西医结合组与西药组总有效率比较差别均有显著意义(P<0.05),说明中药组及中西医结合组治疗效果明显优于西药组,而中药丸剂与汤剂无明显差异。结论循期阴阳序贯疗法主要是通过纠正紊乱的生殖内分泌轴和恢复部分卵巢功能,从而改善卵巢早衰患者的性功能。
Objective To explore the effect of sequential yin and yang sequential therapy on sexual function in patients with premature ovarian failure. Methods Sixty patients were randomly divided into traditional Chinese medicine group, traditional Chinese medicine combined with western medicine group, western medicine group and traditional Chinese medicine group. Zuogui Pill and Yougui Pill were used for the treatment. Western medicine group was given sequential treatment of estrogen and progesterone. Combination of Western medicine with the same group. All patients were treated with 3 cycles for one course of treatment, the total efficacy observed and judged; enzyme-linked immunosorbent assay FSH and E2 before and after treatment and quantitative comparison of sexual function. Results The effective rate of traditional Chinese medicine group was 60%, that of traditional Chinese medicine combined with western medicine group was 75%, and that of western medicine group was 45%. There was no significant difference between traditional Chinese medicine and western medicine group (P> 0.05) (P <0.05), indicating that the traditional Chinese medicine group and the combination of traditional Chinese and Western medicine treatment group was significantly better than the Western medicine group, while the Chinese medicine pills and decoction no significant difference. Conclusion The sequential yin and yang sequential therapy mainly improves the sexual function of patients with premature ovarian failure by correcting the disturbed reproductive endocrine axis and restoring some ovarian functions.