采用微量微生物法对依替米星兔体肌内注射药代动力学进行了研究，检测菌为短小芽胞杆菌。结果：兔体肌内注射依替米星１６ｍｇ／ｋｇ后，①药时曲线符合一房室开放模型；②达峰时间为（０６３±０１８）ｈ，峰浓度为（２４２０±４６４）ｍｇ／Ｌ，药时曲线下面积为（７６８４±１５６０）ｍｇ·ｈ·Ｌ－１，消除半衰期为（１９０±０４４）ｈ。以上结果为依替米星临床合理化用药提供了理论依据 Microemulsion method was used to study the pharmacokinetics of etimicin intramuscular injection in rabbits. The test strain was Bacillus pumilus. RESULTS: After intramuscular injection of etimicin 16mg / kg, the curve of drugtime was consistent with one-compartment open model. ② The peak time was (0.663 ± 0.18) h and the peak concentration was (245) 20 ± 464) mg / L, the area under the curve of drugtime was (7684 ± 1560) mg · h · L-1, and the elimination half-life was (190 ± 0.44) h. The above results provide a theoretical basis for the clinical rationalization of etimicin