论文部分内容阅读
目的:通过电镜技术观察不同运动负荷下心肌胶原纤维的形态学变化特征。方法:将36只Wistar大鼠随机分成对照(C组)、一般运动负荷组(NS组)、超负荷(O组),每组各12只,分别给予一般负荷、中等负荷、超负荷的运动训练。8周后,断头处死,取出心脏左心室前壁、左室乳头肌处两组组织块分别作透射和扫描电镜观察。结果:正常组胶原纤维的形态分为粗纤维、细纤维和微细纤维三种;心肌结构完整。一般运动负荷组,心肌束间或肌束内较粗胶原纤维大量增生;心肌细胞体积略显增大,体积增大。超负荷组,心肌细胞间胶原纤维大量增生,心肌束间或心肌束粗大胶原纤维过度增生。结论:运动超负荷可致胶原纤维增生,从而导致心肌扩张功能与收缩功能的降低。
OBJECTIVE: To observe the morphological changes of myocardial collagen fibers under different exercise loads by electron microscopy. Methods: Thirty-six Wistar rats were randomly divided into control group (C group), normal exercise group (NS group) and overloaded group (O group), with 12 animals in each group. training. After 8 weeks, the rats were killed by decapitation, and the two groups of tissue blocks at the anterior wall of left ventricle and left ventricular were removed for transmission and scanning electron microscopy. Results: The morphology of collagen fibers in normal group was divided into three kinds: crude fiber, fine fiber and fine fiber; the myocardial structure was intact. General exercise load group, myocardial bundle or bundle of coarse collagen fibers within a large number of hyperplasia; myocardial cell volume increased slightly, the volume increases. Overloaded group, myocardial cells between a large number of collagen fibers hyperplasia, myocardial bundle or myocardial bundle coarse collagen fibers hyperplasia. Conclusion: Exercise overload can lead to collagen proliferation, resulting in reduced myocardial dilatation and systolic function.