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目的:探讨放疗对鼻咽癌(NPC)患者生命质量的影响及影响NPC患者生命质量因素。方法:选择2011年10月到2014年10月在我院接受三维适形放疗(3DCRT)或调强放疗(IMRT)的160例首次治疗NPC患者,随机分为3DCRT组和IMRT组,各80例。3DCRT组采用3DCRT治疗,IMRT组采用IMRT治疗。采用生命质量测定量表(QLQ-C30)分别在治疗结束时、治疗结束后3个月、治疗结束后1年对两组患者进行问卷调查,分析影响NPC患者总体生命质量的危险因素。结果:在不同时间点,IMRT组患者的总体生命质量评分、社会功能评分、家庭经济评分均明显低于3DCRT组(P<0.05)。经过非条件二分类Logistic回归分析显示,影响NPC患者总体生命质量的因素有放疗方式、年龄、是否同期化疗及经济状况。结论:与3DCRT组相比,IMRT能改善患者总体生命质量、社会功能等,放疗方式、年龄、是否同期化疗及经济状况是NPC患者生命质量的影响因素。
Objective: To investigate the effect of radiotherapy on the quality of life of patients with nasopharyngeal carcinoma (NPC) and the factors influencing the quality of life of patients with NPC. Methods: A total of 160 first-time NPC patients who underwent three-dimensional conformal radiotherapy (3DCRT) or IMRT in our hospital from October 2011 to October 2014 were randomly divided into 3DCRT group and IMRT group, 80 cases in each group . 3DCRT group using 3DCRT treatment, IMRT group using IMRT treatment. Quality of life measures (QLQ-C30) were used to investigate the risk factors affecting the overall quality of life of NPC patients at the end of treatment, 3 months after the end of treatment and 1 year after the end of treatment, respectively. Results: The overall quality of life score, social function score and family economic score of IMRT group were significantly lower than those of 3DCRT group at different time points (P <0.05). Logistic regression analysis showed that the factors affecting the overall quality of life of patients with NPC are radiotherapy, age, whether the same period of chemotherapy and economic status. Conclusion: Compared with 3DCRT group, IMRT can improve overall quality of life, social function, radiotherapy method, age, whether chemotherapy and economic status are the influencing factors of quality of life in patients with NPC.