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目的探讨2型糖尿病(T2DM)患者血清IL-6水平与颈动脉内膜中层厚度(CIMT)和糖尿病病程的关系。方法 T2DM患者61例分为CIMT增厚组(A组,CIMT≥1.0mm,33例)和CIMT正常组(B组,<1.0mm,28例);另选取40例无T2DM正常人,分为CIMT增厚组(C组,CIMT≥1.0mm,18例)和CIMT正常组(D组,<1.0mm,22例)。记录四组年龄、T2DM病程、SBP、DBP及CIMT,检测血清IL-6、TG、TC、HDL-C、LDL-C、HbA1c、超敏C反应蛋白(hsCRP)等指标。结果 A组病程、TG、IL-6水平均高于B组(P<0.05)。A、B组血清IL-6和HbA1c水平高于C、D组(P<0.05)。IL-6水平与CIMT、病程、hsCRP、TG和HbA1c呈正相关(r=0.692、0.687、0.275、0.448和0.395,P<0.01),与HDL-C呈负相关(r=-0.221,P<0.05)。CIMT和病程是T2DM患者血清IL-6水平的独立影响因素(P<0.01)。结论 T2DM患者IL-6水平增高,且与CIMT和病程呈正相关。
Objective To investigate the relationship between serum IL-6 level and carotid artery intima-media thickness (CIMT) and diabetes duration in type 2 diabetes mellitus (T2DM). Methods Sixty-one patients with T2DM were divided into two groups: CIMT thickened group (group A, CIMT≥1.0mm, 33cases) and CIMT normal group (B group, <1.0mm, 28cases) CIMT thickening group (C group, CIMT≥1.0mm, 18 cases) and CIMT normal group (D group, <1.0mm, 22 cases). Serum levels of IL-6, TG, TC, HDL-C, LDL-C, HbA1c and hsCRP were measured in four groups of patients with age, T2DM duration, SBP, DBP and CIMT. Results The course of disease, TG and IL-6 in group A were higher than those in group B (P <0.05). The levels of serum IL-6 and HbA1c in group A and B were higher than those in group C and D (P <0.05). The level of IL-6 was positively correlated with CIMT, duration of disease, hsCRP, TG and HbA1c (r = 0.692,0.687,0.275,0.448 and 0.395, P <0.01), but negatively correlated with HDL- ). CIMT and duration of disease were independent determinants of serum IL-6 levels in T2DM patients (P <0.01). Conclusion The level of IL-6 in patients with T2DM is increased, which is positively correlated with the duration of CIMT.