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本文检测了甲氧苄基葡糖胺二硫代羧酸钠(MeOBGDTC)作为镉中毒拮抗剂的效果。测定小鼠急性腹腔注射氯化镉的LD_(50)为0.023mmolCd/kg,95%可信限为0.021～0.026mmolCd/kg。测定腹腔注射和胃管注入MeOBGDTC拮抗急性镉中毒的致死效应和降低组织镉含量的能力。结果表明,腹腔注射MeOBGDTC能够拮抗镉中毒的致死效应,增加小鼠的存活率。腹腔注射MeOBGDTC的小鼠肝肾镉含量均显著低于对照组。结果提示,MeOBGDTC是一种有发展前途的络合剂,值得进一步深入研究。
This article examined the effect of MeOBGDTC as a cadmium poisoning antagonist. The LD_ (50) of acute intraperitoneal injection of cadmium chloride in mice was determined to be 0.023 mmol Cd / kg and the 95% confidence limit was 0.021 ~ 0.026 mmol Cd / kg. The ability of MeOBGDTC to antagonize the lethal effect of acute cadmium poisoning and reduce the content of cadmium in tissues was determined by intraperitoneal injection and gastric tube injection. The results showed that intraperitoneal injection of MeOBGDTC can antagonize the lethal effect of cadmium poisoning and increase the survival rate of mice. Intraperitoneal injection of MeOBGDTC mice liver and kidney cadmium levels were significantly lower than the control group. The results suggest that MeOBGDTC is a promising complexing agent and deserves further study.