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集落刺激因子(CSF)是一组糖蛋白物质,包括粒细胞集落刺激因子(G-CSF)、粒一巨噬细胞集落刺激因子(GM-CSF)等,在体外实验刺激粒一巨噬祖细胞增殖、形成集落。近年来国外有报导G-CSF、GM-CSF在体内也能促进造血,升高周围血白细胞,也有报导应用重组的G-CSF、GM-CSF治疗疾病,取得良好的疗效。我们以胎盘条件培养液(HPCM)为CSF来源,在动物体内应用,观察CSF对拉一巨噬系祖细胞(CFU-GM)增殖的影响,以及提升周围血白细胞的影响。
Colony stimulating factor (CSF) is a group of glycoprotein substances, including granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), etc., in vitro stimulation of granulosa macrophage progenitor cells Proliferation, the formation of colonies. In recent years, foreign reports of G-CSF, GM-CSF in vivo can also promote hematopoietic, peripheral white blood cells increased, there are also reports of recombinant G-CSF, GM-CSF treatment of disease, and achieved good results. We used placental conditioned medium (HPCM) as a source of CSF and applied it in animals to observe the effect of CSF on the proliferation of CFU-GM and the effect of peripheral blood leukocytes.