NK细胞能在体内外杀伤各种瘤细胞,但并非所有的肿瘤对NK的杀伤都敏感。许多肿瘤.特别是由体内原发肿瘤部位及转移灶中分离的瘤细胞对NK的结合及杀伤表现出不同程度的抗性。不同的瘤细胞对NK杀伤敏感性上的差异与这些细胞表面“NK靶细 NK cells kill various tumor cells both in vitro and in vivo, but not all tumors are sensitive to NK killing. Many tumors, especially the tumor cells isolated from the primary tumor sites and metastases in the body, show different degrees of resistance to NK binding and killing. Differences in sensitivity to NK cytotoxicity of different tumor cells were associated with NK cell death on these cell surfaces