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众所周知,人体红细胞内2,3-二磷酸甘油酸含量增加并伴有糖酵解活性提高时,其血红蛋白对氧的亲和力下降。本文报道外伤(骨折、脱位、烧伤)能引起血红蛋白对氧的亲和力下降,使氧解离曲线右移。因此分析血红蛋白对氧的亲和力具有诊断意义。作者研究了25例正常人和30例外伤病人的血样品。琼脂电泳结果显示,正常人和外伤病人的血红蛋白组成成分没有显著差别,而人体在外伤后1/2-1小时,血红蛋白对氧的亲和力即有明显改变,P_(50)平均值和正常人(25.9毫米汞柱)相比,增加4.5毫米汞柱,达到30.4毫米汞柱。透析处理除去有机磷酸酯后,对氧的亲和力差别消失。所以作者认为,亲和力的降低不是由于血红蛋白本身改变所引起的,而是由于红细胞内部环境的影响。直到病人出
It is well-known that the increase of 2,3-diphosphoglycerate content in human erythrocytes with the accompanying increase of glycolysis activity decreases the affinity of hemoglobin for oxygen. This article reports that trauma (fracture, dislocation, burns) can cause the hemoglobin affinity for oxygen decreased, so that the oxygen dissociation curve to the right. Therefore, the analysis of the affinity of hemoglobin for oxygen is of diagnostic significance. The authors studied blood samples from 25 normal subjects and 30 trauma patients. Agar electrophoresis results showed that there was no significant difference in hemoglobin composition between normal and traumatic patients, while the body’s hemoglobin affinity to oxygen changed obviously after 1 / 2-1 hour after trauma. The average value of P_ (50) and normal 25.9 mmHg), an increase of 4.5 mmHg to 30.4 mmHg. Dialysis treatment to remove the organic phosphate, the affinity for oxygen differences disappear. Therefore, the author believes that the reduction in affinity is not due to hemoglobin itself caused by changes, but because of the internal environment of red blood cells. Until the patient out