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为探讨米非司酮配伍前列腺素终止早孕的最小有效剂量及服用方法,我院对180例妊娠35～49天的健康妇女,按服药天数的不同分为两组:对照组服用米非司酮25mg一日二次,连服三天,第四天上午顿服米索前列醇600μg。实验组服用米非司酮25mg一日二次,连服二天,第三天上午顿服米索前列醇600μg。两组完全流产有效率分别为96.6％和95.6％,无明显差异。而胃肠道反应,实验组由于服药天数少,药物总剂量小,反应较对照组轻。提示:米非司酮配伍前列腺素抗早孕的有效量可进一步减少。
In order to explore the minimum effective dose of mifepristone combined with prostaglandin termination of early pregnancy and taking the method of 180 cases of pregnant women in our hospital 35 to 49 days of healthy women, divided by the number of days into different groups: the control group taking mifepristone 25mg twice a day, and even served three days, the fourth day of tomorrow morning serving misoprostol 600μg. Experimental group taking mifepristone 25mg twice a day, and even served two days, the third day of the morning suddenly served misoprostol 600μg. Two groups of complete abortion effective rates were 96.6% and 95.6%, no significant difference. The gastrointestinal reaction, the experimental group due to less medication days, the total dose of drugs, the reaction lighter than the control group. Tip: mifepristone compatibility prostaglandin anti-early pregnancy effective amount can be further reduced.