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脊柱关节病(SpA) 这大类病包括强直性脊柱炎(AS)、Reiter综合征、银屑病脊柱关节炎、炎性肠病脊柱关节病和反应性关节炎。这类病的共同点:在基因水平与HLA-B27有密切相关性,在病理是附着点炎(enthesitis),在临床上是骶髂关节炎和脊柱炎。在我国大陆初步的流行病学调查其患病率为0.2％～0.3％,在台湾省的不同地区为0.2％～0.4％。HLA-B27在AS的发病机制中的相关性再次被提出,首先在AS中只有95％具有B27基因,在其他SpA中B27频率更低,B27的亚型也可能影响B27是SpA发病的重要因素。美国Khan MA报道HLA-B27有16个亚型,即B~*2701～2716,在中国人和日本人中最常见的亚型为B~*2704,在泰国人中的常见型为B~*2704和~*2706,印度的北方人中为B~*2705,在印尼人中常见为B~*2706,通过规范的流行病学调查可以看到亚型B~*
Spondyloarthropathy (SpA) This broad class of diseases includes ankylosing spondylitis (AS), Reiter’s syndrome, psoriatic spondylarthritis, inflammatory bowel disease and reactive arthritis. The commonalities of these diseases are closely related to HLA-B27 at the gene level, enthesitis in the pathology, and sacroiliitis and spondylitis clinically. The preliminary epidemiological survey in mainland China showed a prevalence of 0.2% -0.3% and 0.2% -0.4% in different regions of Taiwan. The association of HLA-B27 in the pathogenesis of AS was again demonstrated, with only 95% of B27 genes in AS and lower in other SpA subtypes, and the B27 subtype may also affect B27 as an important factor in the pathogenesis of SpA . Khan MA reported that HLA-B27 has 16 subtypes, B ~ * 2701 ~ 2716, the most common subtype of B * 2704 in Chinese and Japanese, and B ~ * 2704 and ~ 2706, B ~ * 2705 among northerners in India and B ~ * 2706 among Indonesian people. Subclass B ~ * can be seen through standardized epidemiological survey.