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在静息状态下,人体肺部每分钟进出的空气大约有5-8升,其中含有大量的过敏原物质。这些信号能够被肺部表面的细胞识别并传递引发一系列生理反应,包括肺部血压,免疫反应,呼吸节律等方面,然而其中的机制并不清楚。肺部神经内分泌细胞(Pulmonary neuroendocrine cells,PNECs)是存在于肺部的一种细胞类型,占全部表皮细胞的1%。此前的体外研究结果表明PNEC对于感受氧气、肺部及支气管组织平滑肌运动以及免疫反应具有重要作用,但一直缺乏体内的证据。一些临床证据表明肺部的常
At rest, the human lungs have approximately 5-8 liters of air entering and leaving the lungs each minute, which contains large amounts of allergens. These signals can be recognized by cells on the surface of the lungs and transmitted to trigger a series of physiological reactions, including pulmonary blood pressure, immune response, respiratory rhythm and so on, but the mechanism is not clear. Pulmonary neuroendocrine cells (PNECs) are a type of cell that is present in the lungs, accounting for 1% of all epidermal cells. Previous in vitro studies have shown that PNEC plays an important role in the perception of smooth muscle movement and immune responses in oxygen, lung and bronchial tissue but has been lacking in vivo evidence. Some clinical evidence suggests that the lungs often