目的探索左氧氟沙星与喘定合用致严重不良反应的特点。方法通过对5例左氧氟沙星与喘定合用致精神异常5例分析,对左氧氟沙星和喘定相互作用和不良反应的特点提出合理用药建议。结果左氧氟沙星和喘定联合应用不当可产生严重精神异常反应。结论左氧氟沙星和喘定联合应用应适当调整药物剂量,以减少不良反应的发生。 Objective To explore the levofloxacin combined with asthma caused by serious adverse reactions. Methods Based on the analysis of 5 cases of mental abnormalities caused by levofloxacin combined with asthma in 5 cases, the rational use of drugs for the interaction and adverse reactions of levofloxacin and asthma was proposed. Results Levofloxacin and asthma combined improper application can produce severe mental abnormalities. Conclusion The combination of levofloxacin and asthma should be appropriately adjusted drug dose, in order to reduce the incidence of adverse reactions.