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目的:探讨三维适形加量放射治疗在纵隔转移肿瘤中的应用。方法:66例纵隔转移肿瘤患者随机分为两组,普放组和普放+三维适形组,每组33例。结果:近期疗效两组分别为:完全缓解(CR)率11%、23%,部分缓解(PR)率60%、71%,无进展(NR)率29%、6%。两组1+2级急性放射性肺炎发生率37%、19%、1+2级急性放射性食管炎发生率52%、35%。两组间1+2级急性放射性肺炎和急性放射性食管炎有显著性差异。结论:三维适形加量放射治疗在纵隔转移肿瘤中有良好的应用,近期疗效好于普放治疗,远期疗效有待进一步观察。
Objective: To investigate the application of three-dimensional conformal plus radiation therapy in mediastinal metastatic tumors. Methods: Sixty-six patients with mediastinal metastatic tumors were randomly divided into two groups, Pulsed-placed group and normal-discharged + three-dimensional conformal group. There were 33 cases in each group. Results: The short-term efficacy of the two groups were as follows: complete remission (CR) rate was 11%, 23%, partial remission (PR) rate was 60%, 71%, and no progress (NR) rate was 29%, 6%. The incidence rate of acute radiation pneumonitis 1 + 2 in the two groups was 37%, 19%, and 1 + 2 grades of acute radiation esophagitis were 52% and 35%. There was a significant difference in acute radiation pneumonitis 1+2 and acute radiation esophagitis between the two groups. Conclusion: Three-dimensional conformal plus radiation therapy has a good application in mediastinal metastatic tumors. The recent curative effect is better than that of conventional radiotherapy. The long-term efficacy needs to be further observed.