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目的探讨分次小剂量他巴唑治疗甲亢的临床疗效和副作用的发生情况。方法选择2009-2012年来我门诊就诊并经他巴唑治疗的64例病人,根据病人的病情严重程度,每日分2～3次口服他巴唑10～20mg。结果治疗后随访1年以上,64例病人中治愈56例,治愈率为87.5%;不同甲状腺肿大程度的病人治疗情况差异无统计学意义(χ2=4.156,P>0.05);突眼型的病人比单纯型的病人治愈率低(χ2=8.145,P<0.001);4例出现一过性甲低,甲低发生率为6.3%;3例复发,复发率为4.7%;未出现粒细胞减少、甲状腺危象等严重不良反应。结论分次小剂量他巴唑治疗甲亢是一种经济、方便、可行的治疗方法。
Objective To investigate the clinical efficacy and side effects of metoprolol treated with small doses of metoprolol. Methods Sixty-four patients who were treated in our clinic from 2009 to 2012 and treated with methimazole were given 10 ~ 20 mg oral methimazole 2 ~ 3 times a day according to the severity of their illness. Results The patients were followed up for more than one year, 56 of 64 patients were cured, the cure rate was 87.5%. There was no significant difference in the treatment of patients with different degrees of goiter (χ2 = 4.156, P> 0.05) The patients had a lower cure rate (χ2 = 8.145, P <0.001) than the simple type (χ2 = 8.145, P <0.001). Four patients had transient hypothyroidism with a hypothyroidism rate of 6.3%, 3 patients relapsed with a recurrence rate of 4.7%, and no granulocytes Reduce, thyroid crisis and other serious adverse reactions. Conclusion Small dose of methimazole treatment of hyperthyroidism is an economical, convenient and feasible treatment.