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目的:通心络胶囊与硝酸异山梨醇酯治疗冠心病心绞痛的疗效。方法:研究选取我院2014年1月—2016年1月就诊的60例冠心病心绞痛患者。随机分组方法为中心随机系统法。60例患者分为对照组和观察组。对照组治疗药物采用硝酸异山梨醇酯;观察组治疗药物采用通心络胶囊。比较:冠心病心绞痛症状疗效和心电图疗效;副作用发生情况;干预前和干预后患者血脂指标总胆固醇,高、低密度脂蛋白胆固醇,甘油三酯的差异;干预前和干预后患者CI、E峰加速时间、LVEF、SV的差异;干预前和干预后患者睡眠质量评分、生活质量评分的差异。结果:(1)观察组对比对照组冠心病心绞痛症状疗效和心电图疗效更高,P<0.05。(2)两组患者均无严重药物副作用发生,P>0.05。(3)干预前两组血脂指标总胆固醇,高、低密度脂蛋白胆固醇,甘油三酯相似,P>0.05;干预后观察组对比对照组血脂指标总胆固醇,高、低密度脂蛋白胆固醇,甘油三酯改善更显著,P<0.05。(4)干预前两组CI、E峰加速时间、LVEF、SV相似,P>0.05;干预后观察组对比对照组CI、E峰加速时间、LVEF、SV改善更显著,P<0.05。(5)干预前两组睡眠质量评分、生活质量评分相似,P>0.05;干预后观察组对比对照组睡眠质量评分、生活质量评分改善更显著,P<0.05。结论:通心络胶囊与硝酸异山梨醇酯治疗冠心病心绞痛的疗效确切,可有效改善患者血脂水平、心功能,促进其睡眠质量和生活质量的改善,作用安全可靠,无严重不良反应发生,值得推广应用。
Objective: To investigate the curative effect of Tongxinluo capsule and isosorbide dinitrate on angina pectoris of coronary heart disease. Methods: A total of 60 patients with coronary heart disease were selected from January 2014 to January 2016 in our hospital. Random grouping method is the central random system method. 60 patients were divided into control group and observation group. The control group was treated with isosorbide dinitrate; the observation group was treated with Tongxinluo capsule. Comparison of curative effect of coronary heart disease angina pectoris and electrocardiogram curative effect; occurrence of side effect; Difference of total cholesterol, high and low density lipoprotein cholesterol and triglyceride in patients before and after intervention; CI and E peak before and after intervention Acceleration time, LVEF, SV; differences in sleep quality scores and quality of life scores before and after intervention. Results: (1) Compared with control group, the curative effect of angina pectoris and electrocardiogram in observation group were higher (P <0.05). (2) No serious side effects occurred in both groups, P> 0.05. (3) The levels of total cholesterol, high and low density lipoprotein cholesterol and triglyceride in the two groups before intervention were similar, P> 0.05. After intervention, the levels of total cholesterol, high and low density lipoprotein cholesterol, Triester improved more significantly, P <0.05. (4) The CI, E peak acceleration time, LVEF and SV were similar in the two groups before intervention (P> 0.05). After intervention, the CI and E peak acceleration time, LVEF and SV in the observation group were more significant (P <0.05). (5) The scores of sleep quality in the two groups before intervention were similar, and the quality of life scores were similar (P> 0.05). After the intervention, the sleep quality scores and the quality of life scores of the observation group and control group improved more significantly (P <0.05). Conclusion: The effect of Tongxinluo capsule and isosorbide dinitrate in the treatment of angina pectoris is exact, which can effectively improve the level of blood lipid and heart function, improve the quality of sleep and quality of life of the patients. The effect is safe and reliable without serious adverse reactions. Worth promoting application.