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目的 :探讨红细胞膜脂质成份及四种元素的变化与妊高征的关系 ,了解妊高征的病理生理过程。方法 :采用比色法、气相色谱法、全自动生化分析仪及原子吸收分光光度法对 2 2例正常孕妇及 3 6例妊高征病人红细胞膜胆固醇、磷脂、脂肪酸及钙、镁、锌、铜离子的含量进行了测定。结果 :①中、重度妊高征患者红细胞膜胆固醇含量及胆固醇 /磷脂的比值均显著高于正常妊娠及健康未妊娠组 (P <0 0 1) ;②妊高征红细胞膜钙、镁离子含量及铜 /锌比值均显著低于正常妊娠组 ,锌高于正常妊娠组 ,铜与正常妊娠间无显著差异 (P >0 0 5 )。结论 :红细胞膜胆固醇含量及胆固醇 /磷脂比值的升高及四种元素的变化参与了妊高征的病理生理过程
Objective: To investigate the relationship between lipid composition and four elements in erythrocyte membrane and pregnancy-induced hypertension (PIH) and to understand the pathophysiological process of PIH. Methods: The contents of cholesterol, phospholipids, fatty acids, calcium, magnesium, zinc, calcium and magnesium in erythrocytes of 22 normal pregnant women and 36 cases of pregnancy induced hypertension were measured by colorimetric method, gas chromatography, automatic biochemical analyzer and atomic absorption spectrophotometry The content of copper ions was measured. Results: ① The ratio of erythrocyte membrane cholesterol and cholesterol / phospholipid in patients with moderate and severe pregnancy-induced hypertension were significantly higher than those in normal pregnancy and healthy nonpregnant women (P <0.01). ② The content of calcium and magnesium in membrane of PIH erythrocytes And copper / zinc ratio were significantly lower than the normal pregnancy group, zinc higher than the normal pregnancy group, copper and normal pregnancy no significant difference (P> 0.05). Conclusion: The red cell membrane cholesterol content and cholesterol / phospholipid ratio and the changes of four elements involved in the pathophysiology of pregnancy-induced hypertension