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目的 评价以血红蛋白为指标诊断孕妇缺铁性贫血(IDA)与血清铁蛋白和红细胞游离原卟啉变化的符合程度。方法 对506名不同孕周孕妇的血红蛋白、血清铁蛋白和红细胞游离原卟啉进行检测,分别以血红蛋白<100g/L、<105g/L和<110g/L作为诊断IDA的界限值,应用Kappa分析方法分别分析了血红蛋白与血清铁蛋白和红细胞游离原卟啉检测的一致性。结果 21孕周前,血红蛋白的3种界限值与血清铁蛋白、红细胞游离原卟啉诊断的一致性普遍较差;21孕周后,以血红蛋白<105g/L和<110g/L为界值,血红蛋白与血清铁蛋白和红细胞游离原卟啉诊断的一致性普遍较好,但以血红蛋白<100g/L为界限值与血清铁蛋白、红细胞游离原卟啉诊断的一致性相对较差。结论 血红蛋白与血清铁蛋白和红细胞游离原卟啉检测孕妇IDA的一致性,与孕周以及血红蛋白的界限值有关。
Objective To evaluate the coincidence of hemoglobin as a marker for the diagnosis of iron deficiency anemia (IDA) in pregnant women and the changes of serum ferritin and erythrocyte free protoporphyrin. Methods The hemoglobin, serum ferritin and erythrocyte free protoporphyrin in 506 pregnant women with different gestational weeks were detected. The diagnostic limits of IDA were respectively determined by hemoglobin <100g / L, <105g / L and <110g / L. Kappa analysis Methods The consistency between hemoglobin, serum ferritin and erythrocyte free protoporphyrin was analyzed. Results Before the first trimester of 21 gestational weeks, the three thresholds of hemoglobin were not consistent with those of serum ferritin and erythrocyte free protoporphyrin. After 21 weeks of gestation, the hemoglobin values of <105g / L and <110g / L, The agreement between hemoglobin and serum ferritin and erythrocyte free protoporphyrin was generally good, but the consistency between hemoglobin <100g / L and serum ferritin and erythrocyte free protoporphyrin was relatively poor. Conclusions The consistency of hemoglobin, serum ferritin and erythrocyte free protoporphyrin in detecting IDA in pregnant women is related to gestational age and hemoglobin limit.