论文部分内容阅读
CD4+CD25+调节性T细胞(Treg)对维持自身免疫耐受及调控免疫应答水平发挥非常重要的作用.Treg的缺失或紊乱导致如多发性硬化症、1型糖尿病等自身免疫性疾病的发生.研究发现,Treg在肿瘤免疫、感染免疫和移植免疫耐受中也发挥关键作用.根据来源不同,可将Treg分为胸腺来源的天然型Treg(natural Treg)和外周诱导型Treg(induced Treg)两群.天然型Treg(nTreg)是由胸腺发育分化成熟的,nTreg存在于胸腺CD4单阳性细胞中,表达CD4、CD25及叉头转录因子Foxp3,主要通过细胞与细胞之间直接接触发挥免疫抑制功能.研究表明,nTreg在胸腺中发育分化受到十分复杂的细胞、分子网络调控.胸腺微环境、T细胞受体、共刺激分子、IL-2等信号都可影响nTreg的发育分化.本文将主要对胸腺nTreg的发育分化过程及分子调控等方面进行综述.
CD4 + CD25 + regulatory T cells (Tregs) play an important role in maintaining autoimmune tolerance and modulating the immune response.Deletion or disruption of Tregs leads to autoimmune diseases such as multiple sclerosis and type 1 diabetes. Treg also plays a key role in tumor immunity, immune tolerance and transplantation immune tolerance.According to different sources, Treg can be divided into two groups: natural Treg (thymus-derived) and induced Treg The natural Tregs (nTregs) are differentiated and mature from the thymus, nTregs are present in thymus CD4 single positive cells, express CD4, CD25, and forkhead transcription factor Foxp3 and function as immunosuppressors primarily through direct cell-cell contact Studies have shown that the development and differentiation of nTreg in the thymus are very complex cell and molecular network regulation.Thymus microenvironment, T cell receptors, costimulatory molecules, IL-2 and other signals can affect the development and differentiation of nTreg.This article will be the main Thymus nTreg development and differentiation process and molecular regulation and so on.