论文部分内容阅读
目的探讨鲍氏不动杆菌的多药耐药与Ⅰ类整合子的相关性。方法收集39株医院感染多药耐药鲍氏不动杆菌株及41株非多药耐药鲍氏不动杆菌株,以纸片扩散法敏感试验(K-B法)检测其耐药表型,以聚合酶链反应(PCR)方法检测Ⅰ类整合子的分布情况,分析Ⅰ类整合子与细菌耐药表型的相关性。结果鲍氏不动杆菌对多种抗菌药物的耐药率均较高,除对亚胺培南、头孢哌酮/舒巴坦、环丙沙星、阿米卡星、哌拉西林/他唑巴坦敏感率较高外,对其他抗菌药物的耐药率均>40.0%;多药耐药鲍氏不动杆菌中Ⅰ类整合子阳性率为82.1%,非多药耐药菌株阳性率为26.8%,多药耐药菌与非多药耐药菌株Ⅰ类整合子阳性率差异有统计学意义(2χ=24.6,P<0.01);比较研究Ⅰ类整合子阳性菌株耐药表型与Ⅰ类整合子阴性菌株耐药表型发现,除了对亚胺培南敏感率均较高,对氨曲南均耐药,两者耐药率之间差异无统计学意义外,对其他抗菌药物耐药率差异均有统计学意义(P<0.05)。结论Ⅰ类整合子的表达与鲍氏不动杆菌多药耐药密切相关。
Objective To investigate the relationship between multidrug resistance and class Ⅰ integron in Acinetobacter baumannii. Methods 39 hospital-acquired multidrug-resistant Acinetobacter baumannii strains and 41 non-multidrug-resistant Acinetobacter baumannii strains were collected and tested for drug resistance phenotype by disk diffusion method (KB method) The distribution of class Ⅰ integron was detected by polymerase chain reaction (PCR), and the correlation between class Ⅰ integron and bacterial resistance phenotype was analyzed. Results Acinetobacter baumannii showed a high resistance rate to various antimicrobial agents except imipenem, cefoperazone / sulbactam, ciprofloxacin, amikacin, piperacillin / tazobactam The positive rate of Barton was higher than that of other antibacterials. The positive rate of class I integrons in multidrug-resistant Acinetobacter baumannii was 82.1%. The positive rate of non-multidrug-resistant strains was 26.8%. The positive rate of integron of multidrug-resistant and non-multi-drug resistant strains was statistically different (2χ = 24.6, P <0.01) The anti-integron-negative strains showed that, in addition to the high susceptibility to imipenem and resistance to aztreonam, there was no significant difference between the two drug resistance rates, but the resistance to other antibiotics There were significant differences in drug rates (P <0.05). Conclusion The expression of class Ⅰ integron is closely related to multidrug resistance of Acinetobacter baumannii.