细胞周期的失调是肿瘤发生的重要原因。p27为CIP/KIP家族的主要成员,具有阻滞细胞通过G1期或S期的关卡作用,其蛋白表达水平及活性改变与肿瘤形成有关〔1〕。目前研究发现,Jab1能特异性地与p27发生相互作用,使p27由胞核穿梭移动到胞质,通过泛素-蛋白酶体系统加速p27的降解而降低 Cell cycle disorders is an important cause of cancer. P27 is a major member of the CIP / KIP family, with a block of cells through the G1 phase or S phase of the checkpoint, the protein expression level and activity changes associated with tumor formation 〔1〕. The current study found that, Jab1 can specifically interact with p27, the p27 by the nuclear shuttle to the cytoplasm, ubiquitin - proteasome system to accelerate the degradation of p27 decreased