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目的探讨川芎、延胡索中主要活性成分在模型与正常大鼠体内药动学规律与差异。方法 SD大鼠分为对照组和子宫内膜异位症模型组,每组8只,各组均按川芎嗪50mg/kg、阿魏酸30mg/kg、延胡索乙素20mg/kg ig给药,采用高效液相色谱法测定各组大鼠血浆中川芎嗪、阿魏酸和延胡索乙素的质量浓度,DAS2.0程序计算药动学参数。结果模型组川芎嗪药时曲线下面积(AUC_(0~t))、达峰浓度(C_(max))、达峰时间(t_(max))、半衰期(t_(1/2))和平均驻留时间(MRT_(0~t))与对照组相比差异均不显著(P>0.05);模型组阿魏酸AUC_(0~t)、C_(max)、t_(max)都小于对照组,但差异没有显著性(P>0.05),t_(1/2)、MRT_(0~t)显著小于对照组(P<0.05);模型组延胡索乙素AUC_(0~t)、t_(max)、MRT_(0~t)均显著大于对照组(P<0.05)。结论川芎、延胡索主要活性成分在正常大鼠和模型大鼠的体内过程有所不同。阿魏酸在模型大鼠体内消除更快,延胡索乙素在模型大鼠体内吸收浓度更高、消除更慢,川芎嗪在正常及模型大鼠的体内过程无显著性差异。
Objective To investigate the pharmacokinetics and the differences of the main active components of Rhizoma Chuanxiong and Rhizoma Corydalis in the model and normal rats. Methods SD rats were divided into control group and endometriosis model group, with 8 rats in each group. All rats were given ligustrazine 50 mg / kg, ferulic acid 30 mg / kg and tetrahydropalmatine 20 mg / kg ig, The plasma concentrations of ligustrazine, ferulic acid and tetrahydropalmatine in each group were determined by high performance liquid chromatography (HPLC). The pharmacokinetic parameters were calculated by DAS 2.0 program. Results The area under the curve (AUC 0 ~ t), peak concentration (C max), peak time (t max), half life (t 1/2) There was no significant difference between the two groups (P> 0.05). The AUC_ (0 ~ t), C_ (max) and t_ (max) of the ferulic acid in the model group were all less than those in the control (0 ~ t), t_ (0 ~ t) in model group were significantly lower than those in control group (P <0.05) max), MRT_ (0 ~ t) were significantly greater than the control group (P <0.05). Conclusion The main active components of Rhizoma Chuanxiong and Rhizoma Corydalis are different in normal rats and model rats. Ferulic acid in the model rats to eliminate faster, tetrahydropalmatine higher absorption in the model rat body concentration, to eliminate more slowly, ligustrazine in normal and model rats in vivo process was no significant difference.