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胃癌是常见的消化道恶性肿瘤,全球范围内死亡率占第2位,尤其在东北亚地区(中国、日本、韩国)高发[1-2]。由于胃癌细胞自身的生物学异质性,即便接受根治性胃癌切除术,晚期胃癌仍有较高的复发转移风险。其转移复发途径主要有:局部复发、淋巴结转移复发、腹膜种植和血行转移。根据癌细胞转移的解剖/机械假设学说[3],胃癌细胞血行转移到达的第一个靶器官应是肝脏,其次是肺[4-5]。肝脏是胃癌根治术后常见的转移部位,晚期
Gastric cancer is a common malignant tumor of the digestive tract, accounting for the second most common cause of death worldwide, especially in Northeast Asia (China, Japan and Korea) [1-2]. Due to the biological heterogeneity of gastric cancer cells, advanced gastric cancer still has a high risk of recurrence and metastasis even under radical gastric resection. The main pathways of metastasis are: local recurrence, lymph node metastasis and recurrence, peritoneal implantation and hematogenous metastasis. According to the anatomical / mechanical hypothesis of cancer metastasis [3], the first target organ reached by the metastasis of gastric cancer cells is the liver, followed by the lung [4-5]. The liver is a common metastatic site of gastric cancer after radical surgery, advanced