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目的 :了解米非司酮对人早孕蜕膜碱性成纤维细胞生长因子 (basic fibroblast growthfactor,b FGF )的影响 ,探讨药物流产后子宫出血时间长的可能机理。方法 :取正常、服米非司酮、服米非司酮配伍米索前列醇 (米索 )后的早孕蜕膜各 1 5、1 5和 1 6例 ,应用酶联免疫吸附分析法定量测定蜕膜匀浆中 b FGF的水平 ;同时观察子宫出血的持续时间。结果 :正常早孕蜕膜匀浆中 b FGF水平为 2 6 8.81± 75.34pg/ mg蛋白 ;服米非司酮及服米非司酮配伍米索后蜕膜匀浆中 b FGF水平分别为 373.99± 45.94pg/ mg蛋白和 375.6 8±1 0 9.34pg/ mg蛋白。后两者间差异无显著性 (P>0 .0 5) ,但均较正常早孕蜕膜组升高 ,差异有显著性 (P均 <0 .0 1 )。子宫出血持续时间与正常早孕蜕膜组 (7.47± 1 .92 d)比 ,服米非司酮 (1 1 .38± 2 .2 5d)及米非司酮配伍米索组 (1 2 .73± 2 .2 2 d)均延长 ,差异有极显著性 (P均 <0 .0 0 1 ) ,后两者间差异无显著性 (P>0 .0 5)。结论 :米非司酮可使早孕蜕膜b FGF水平升高 ,停用米非司酮可引起子宫出血时间延长 ,药物流产后继续服用米非司酮可望缩短子宫出血时间
Objective: To investigate the effect of mifepristone on the basic fibroblast growth factor (b FGF) in human decidua in early pregnancy and to explore the possible mechanism of prolonged uterine bleeding after medical abortion. Methods: Decidua in normal pregnant women treated with mifepristone and mifepristone combined with misoprostol (misoprostol) were determined by enzyme-linked immunosorbent assay Decidual homogenate b FGF levels; the same time, observe the duration of uterine bleeding. Results: The levels of bFGF in normal early decidua homogenates were 26.881 ± 75.34pg / mg protein. The levels of bFGF in decidual homogenates after mifepristone and mifepristone combined with misoprostol were 373.99 ± 45.94 pg / mg protein and 375.6 8 ± 1 0 9.34 pg / mg protein. There was no significant difference between the two groups (P> 0.05), but both were significantly higher than those in normal decidua group (P <0.01). The duration of uterine bleeding was significantly higher than that of the decidua group (7.47 ± 1.92 days) in the early pregnancy, with mifepristone (11.38 ± 2.25 days) and mifepristone combined with misoprostol (12.23 ± 2 .2 2 d) were longer, the difference was significant (P <0.01), no significant difference between the latter two (P> 0.05). CONCLUSION: Mifepristone can increase the level of b FGF in decidua of early pregnancy. The discontinuation of mifepristone may prolong the time of uterine bleeding, and the continued administration of mifepristone after abortion may shorten the time of uterine bleeding