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我们首次检测并发现30例GBS患儿血清GS-Ab阳性率为26.7％,其他神经疾病(OND)组阳性率为2.8％,两组间有显著性差异(x~2=9.687,P<0.001);GBS患儿血清E-Ab阳性率36.7％,ONT)组阳性率9.3％,正常对照组全部阴性;11例GBS患儿血清E-Ab阳性者中,有GS-Ab阳性8例(72.7％),EAb平均滴度为1:21.9,GS-Ab平均滴度为1:17.5。11例GBS急性期和恢复期,二种血清抗体滴度均呈下降趋势。本文结果提示GS-Ab的存在可能与GBS发病有关。
For the first time, we found that the positive rate of GS-Ab in serum of 30 children with GBS was 26.7% and that of other neurological diseases (OND) was 2.8%. There was significant difference between the two groups (x ~ 2 = 9.687, P <0.001) ). The positive rate of serum E-Ab in GBS children was 36.7%, and the positive rate in ONT group was 9.3%, which was negative in the normal control group. Among the 11 cases of GBS children with positive serum E-Ab, GS-Ab was positive in 8 cases %). The average titer of EAb was 1: 21.9, the average titer of GS-Ab was 1: 17.5. In the 11 acute and convalescent periods of 11 cases of GBS, the titer of both serum antibodies showed a decreasing trend. Our results suggest that the presence of GS-Ab may be related to the pathogenesis of GBS.