权衡药物的疗效和安全性,在药物诞生之初就一直存在。胰岛素类似物作为一种替代人体自身胰岛素的体外激素,尤其是在患者体内长期起效的长效胰岛素类似物,其安全性自然更加受到关注。对低血糖的影响,对体重的影响,以及胰岛素的长期安全性,都对临床一线医生选择胰岛素产生了一定影响。 The trade-off between the efficacy and safety of drugs has always existed at the beginning of the drug. Insulin analogues, as an extra-body hormone that replaces the body’s own insulin, especially the long-acting insulin analogues that have long-term effects in the patient’s body, are naturally of more concern. The effects on hypoglycaemia, body weight, and the long-term safety of insulin all have some impact on the choice of insulin by the clinical frontline physician.