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Background:The risk of radial artery occlusion (RAO) needs particular attention in transradial intervention (TRI).Therefore,reducing vascular occlusion has an important clinical significance.The aim of this study was to determine the appropriate puncture site during TRI through comparing the occurrence of RAO between the different puncture sites to reduce the occurrence of RAO after TRI.Methods:We prospectively assessed the occurrence of RAO in 606 consecutive patients undergoing TRI.Artery occlusion was evaluated with Doppler ultrasound in 2 days and 1 year after the intervention.Risk factors for RAO were evaluated using a multivariate model analysis.Results:Of the 606 patients,the RAO occurred in 56 patients.Compared with TRI at 2-5 cm away from the radius styloid process,the odds ratio (OR) for occlusion risk at 0 cm and 1 cm were 9.65 (P =0.033) and 8.90 (P =0.040),respectively.The RAO occurred in the ratio of the arterial diameter to the sheath diameter ≤1 (OR =2.45,P =0.004).Conclusion:Distal puncture sites (0-1 cm away from the radius styloid process) can lead to a higher rate of RAO.