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目的研究清肺止咳灵糖浆对慢性支气管炎急性发作期的止咳祛痰平喘作用。方法通过对SO2致小鼠咳嗽、毛细玻管法测大鼠排痰量、豚鼠磷酸组胺喷雾引喘潜伏期的观察,研究清肺止咳灵糖浆对慢性支气管炎急性发作期的止咳祛痰平喘作用。结果清肺止咳灵糖浆能明显延长小鼠对SO2刺激引起咳嗽的潜伏期(P<0.05),能显著增加大鼠气管排痰量(P<0.05),能明显延长豚鼠磷酸组胺喷雾引喘潜伏期(P<0.05)。结论清肺止咳灵糖浆对慢性支气管炎急性发作期具有明显的止咳祛痰平喘作用。
Objective To study the effect of Qingfeizhilingling syrup on relieving cough, expectorant and antiasthmatic in acute exacerbation of chronic bronchitis. Methods The effects of Qingfei Zhilingling syrup on relieving cough, expectorant and expectoration during the acute episode of chronic bronchitis were studied by observing the latent period of asthma induced by cough, effect. Results Qingfei Zhilingling syrup could prolong the latent period of cough caused by SO2 stimulation (P <0.05), increase the volume of tracheal expectoration (P <0.05), prolong the latent period of asthma induction (P <0.05). Conclusion Qingfei Zhilingling Syrup has significant antitussive, expectorant and antiasthmatic effects on acute exacerbation of chronic bronchitis.