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1 坏死性小肠结肠炎的发病机理及临床坏死性小肠结肠炎(NEC)多发于生后2周内的新生儿,尤以早产儿、低体重儿多见,小婴儿也常可发病。发病机理至今尚未完全阐明,它是由多种有害因素所造成的综合损害。多年研究发现,肠道缺氧缺血是NEC 的重要发病因素,如新生儿窒息,肺透明膜病、休克、低血压、动脉导管未闭等,均可导致肠粘膜缺血性坏死。人工喂养儿,奶液配制过浓,渗透压>460mmol/L,或应用
1 necrotizing enterocolitis pathogenesis and clinical necrotizing enterocolitis (NEC) in multiple births within 2 weeks of newborns, especially premature children, low birth weight more common in infants and young children can often attack. The pathogenesis has not yet been fully elucidated, it is a comprehensive damage caused by a variety of harmful factors. Years of research have found that intestinal hypoxia-ischemia is an important risk factor for NEC, such as neonatal asphyxia, hyaline membrane disease, shock, hypotension, patent ductus arteriosus, etc., can lead to intestinal mucosal ischemic necrosis. Artificial feeding children, concentrated milk preparation, osmolality> 460mmol / L, or application