【摘 要】
：
目的探讨新的肿瘤标志物GP87在老年胃癌及胃癌前病变中表达的情况,从而确定其在上述病变中的应用价值.方法采用sABC免疫组化染色法对283例标本进行染色分析.结果正常胃体、胃
【机 构】
：
白求恩医科大学第二临床医院普外科,长春,130041;解放军总医院肿瘤生物学研究室;白求恩医科大学第一临床医院普外科;Wyome State University
论文部分内容阅读
目的探讨新的肿瘤标志物GP87在老年胃癌及胃癌前病变中表达的情况,从而确定其在上述病变中的应用价值.方法采用sABC免疫组化染色法对283例标本进行染色分析.结果正常胃体、胃窦均为阴性,浅表性胃炎组阳性率为7.1%,明显低于癌症组及癌前病变组(P<0.01).胃癌组阳性率为62.0%,明显低于癌前病变各组阳性率(P<0.05),癌旁粘膜组阳性率亦较高,在80.0%左右.结论新的肿瘤标志物GP87在胃癌及胃癌前病变中均有较高表达,特别是在胃癌前病变中的表达更高,故认为GP87是检测胃癌前病变较好的肿瘤标志物,可用于胃癌高危人群的普查,筛选出具有明确癌前病变的病人,定期随访、长期追踪,无疑有助于发现早期胃癌.
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