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目的 探讨血管紧张素转化酶基因 (ACE)多态性与中国汉族老年人糖耐量低减 (IGT)及合并冠心病 (CAD)的关系。方法 使用多聚合酶链反应方法检测 79例糖耐量低减老年人和 49例糖耐量正常 (NGF)老年对照者的 ACE第 1 6内含子中长度为 2 87bp碱基片段的插入 /缺失(I/ D)情况。结果 IGT组 (n=79)和 NGT组 (n=40 )相比 ,D型等位基因和 DD基因型频率升高 (P<0 .0 5;P<0 .0 0 5) ;IGT合并冠心病组 (n=31 )和 IGT非冠心病组 (n=48)相比 ,DD基因型频率升高 (P<均 0 .0 0 5)。结论 ACE多态性和与老年人糖耐量低减冠心病相关 ,IGT和 DD基因型是老年冠心病的重要危险因子。
Objective To investigate the relationship between angiotensin-converting enzyme (ACE) polymorphism and impaired glucose tolerance (IGT) and coronary heart disease (CAD) in Chinese Han elderly. Methods Polymerase chain reaction (PCR) was used to detect the insertion / deletion of a base pair of 2 87 bp in ACE 1 6 intron in 79 subjects with impaired glucose tolerance and 49 subjects with impaired glucose tolerance (NGF) I / D) situation. Results Compared with NGT group (n = 40), the frequencies of D allele and DD genotype were significantly increased in IGT group (n = 79) (P <0.05; P <0.05) The frequency of DD genotype was higher in CHD patients (n = 31) and IGT non-CHD patients (n = 48) (P <0.05). Conclusion ACE polymorphism is associated with impaired glucose tolerance in the elderly. IGT and DD genotypes are important risk factors for coronary heart disease in the elderly.