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目的评价自由基清除剂依达拉奉治疗脑出血的疗效。方法计算机检索中文科技期刊全文数据库、中国期刊全文数据库、中国生物医学文献数据库、中华医学会数字化期刊,收集所有依达拉奉治疗脑出血的随机对照试验,检索时间截止到2012年5月。两位研究者独立筛选文献、评价文献质量、提取数据,最后采用RevMan5.0软件进行统计处理。结果共纳入20个研究(1967位患者),Meta分析显示依达拉奉治疗后NIHSS评分低于对照组,而ADL评分、有效率、显效率高于对照组。结论就目前研究结果来看,依达拉奉能促进脑出血患者的神经功能恢复,可用于脑出血急性期的治疗。但由于纳入文献质量级别比较低,尚需高质量、多中心的随机对照试验进一步验证。
Objective To evaluate the efficacy of free radical scavenger edaravone in the treatment of cerebral hemorrhage. Methods The computer-aided search of Chinese Science and Technology Periodicals Full-text Database, Chinese Journal Full-text Database, Chinese Biomedical Literature Database, and Chinese Medical Association Digital Periodicals collected randomized controlled trials of all edaravone in the treatment of cerebral hemorrhage. The search time was up to May 2012. The two researchers independently screened the literature, evaluated the quality of the literature, extracted data, and finally used RevMan5.0 software for statistical processing. Results A total of 20 studies (1967 patients) were included. Meta-analysis showed that the NIHSS score of edaravone was lower than that of the control group, while the ADL score, effective rate and markedly effective rate were higher than those of the control group. Conclusion According to the current findings, edaravone can promote the recovery of neurological function in patients with intracerebral hemorrhage and can be used in the treatment of acute cerebral hemorrhage. However, due to the relatively low quality of the included literature, high-quality, multicenter randomized controlled trials are needed for further validation.